In statistics, restricted randomization occurs in the design of experiments and in particular in the context of randomized experiments and randomized controlled trials. Restricted randomization allows intuitively poor allocations of treatments to experimental units to be avoided, while retaining the theoretical benefits of randomization. For example, in a clinical trial of a new proposed treatment of obesity compared to a control, an experimenter would want to avoid outcomes of the randomization in which the new treatment was allocated only to the heaviest patients.
The concept was introduced by Frank Yates (1948) and William J. Youden (1972) "as a way of avoiding bad spatial patterns of treatments in designed experiments."
Other articles related to "restricted randomization, restricted, randomization":
... To balance group sizes in smaller RCTs, some form of "restricted" randomization is recommended ... The major types of restricted randomization used in RCTs are Permuted-block randomization or blocked randomization a "block size" and "allocation ratio" (number of ... This type of randomization can be combined with "stratified randomization", for example by center in a multicenter trial, to "ensure good balance of participant characteristics ...
Famous quotes containing the word restricted:
“Language can only deal meaningfully with a special, restricted segment of reality. The rest, and it is presumably the much larger part, is silence.”
—George Steiner (b. 1929)