Rena may refer to:
- Locations
- Rena, Badajoz, a municipality in Spain
- Rena, Norway, a town in Norway
- People
- Rena Mero, a former WWE Diva better known as Sable
- Rena J. Mosteirin, an author of poetry and fiction.
- Rena Vlahopoulou, Greek actress and singer
- Rena Sofer, American actress
- Rena Kornreich Gelissen, writer and survivor of the Holocaust
- Rena Kubota, a Japanese female kickboxer
- Rena Takase, a Japanese professional wrestle
- Rena Takeshita, a Japanese fashion model / actress
- Rena Dejota, German-Colombian DJ and beatmaker based in Spain.
- Fictional characters
- Cyberdoll Rena from Hand Maid May
- Rena Kunisaki, a fictional character from the manga .hack//Legend of the Twilight
- Rena Ryūgū, from Higurashi no Naku Koro ni
- Rena Sayers, a character from anime series My-Otome
- Other
- MV Rena, a container ship that ran aground off New Zealand in 2011, resulting in an oil spill
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