PTPN11

PTPN11

Identifiers Symbols PTPN11; BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 External IDs OMIM: 176876 MGI: 99511 HomoloGene: 2122 ChEMBL: 3864 GeneCards: PTPN11 Gene EC number 3.1.3.48

Gene Ontology
Molecular function phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
SH3/SH2 adaptor activity
insulin receptor binding
protein binding
protein domain specific binding
receptor tyrosine kinase binding
phospholipase binding
insulin receptor substrate binding
peptide hormone receptor binding
Cellular component nucleus
cytoplasm
mitochondrion
cytosol
protein complex
Biological process DNA damage checkpoint
activation of MAPK activity
triglyceride metabolic process
epidermal growth factor receptor signaling pathway
axon guidance
brain development
heart development
blood coagulation
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
hormone-mediated signaling pathway
cytokine-mediated signaling pathway
T cell costimulation
regulation of cell adhesion mediated by integrin
organ growth
peptidyl-tyrosine dephosphorylation
atrioventricular canal development
ERBB signaling pathway
regulation of multicellular organism growth
hormone metabolic process
glucose homeostasis
innate immune response
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
multicellular organismal reproductive process
genitalia development
inner ear development
leukocyte migration
negative regulation of cortisol secretion
negative regulation of growth hormone secretion
face morphogenesis
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
type I interferon-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
positive regulation of glucose import in response to insulin stimulus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5781 19247 Ensembl ENSG00000179295 ENSMUSG00000043733 UniProt Q06124 P35235 RefSeq (mRNA) NM_002834 NM_001109992 RefSeq (protein) NP_002825 NP_001103462 Location (UCSC) Chr 12:
112.86 – 112.95 Mb Chr 5:
121.13 – 121.19 Mb PubMed search

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Read more about PTPN11:  Structure and Function, Genetic Diseases Associated With PTPN11, Cancer Associated With PTPN11, Interactions

Other articles related to "ptpn11":

GAB2 - Interactions - PTPN11
... Protein tyrosine phosphatase non-receptor 11 (PTPN11) interaction with GAB2 is part of the Ras pathway ... Mutations found in PTPN11 cause disruption in the binding to GAB2 which in turn impairs correct cellular growth ... with JMML show activating mutations in PTPN11 ...