PTPN11

PTPN11

Identifiers Symbols PTPN11; BPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2 External IDs OMIM: 176876 MGI: 99511 HomoloGene: 2122 ChEMBL: 3864 GeneCards: PTPN11 Gene EC number 3.1.3.48

Gene Ontology
Molecular function	• phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • SH3/SH2 adaptor activity • insulin receptor binding • protein binding • protein domain specific binding • receptor tyrosine kinase binding • phospholipase binding • insulin receptor substrate binding • peptide hormone receptor binding
Cellular component	• nucleus • cytoplasm • mitochondrion • cytosol • protein complex
Biological process	• DNA damage checkpoint • activation of MAPK activity • triglyceride metabolic process • epidermal growth factor receptor signaling pathway • axon guidance • brain development • heart development • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • hormone-mediated signaling pathway • cytokine-mediated signaling pathway • T cell costimulation • regulation of cell adhesion mediated by integrin • organ growth • peptidyl-tyrosine dephosphorylation • atrioventricular canal development • ERBB signaling pathway • regulation of multicellular organism growth • hormone metabolic process • glucose homeostasis • innate immune response • negative regulation of insulin secretion • regulation of protein export from nucleus • positive regulation of hormone secretion • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • phosphatidylinositol-mediated signaling • multicellular organismal reproductive process • genitalia development • inner ear development • leukocyte migration • negative regulation of cortisol secretion • negative regulation of growth hormone secretion • face morphogenesis • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway • positive regulation of glucose import in response to insulin stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5781 19247 Ensembl ENSG00000179295 ENSMUSG00000043733 UniProt Q06124 P35235 RefSeq (mRNA) NM_002834 NM_001109992 RefSeq (protein) NP_002825 NP_001103462 Location (UCSC) Chr 12:
112.86 – 112.95 Mb Chr 5:
121.13 – 121.19 Mb PubMed search

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.

PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.