PTPN11
| Gene Ontology | |
|---|---|
| Molecular function | • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • SH3/SH2 adaptor activity • insulin receptor binding • protein binding • protein domain specific binding • receptor tyrosine kinase binding • phospholipase binding • insulin receptor substrate binding • peptide hormone receptor binding |
| Cellular component | • nucleus • cytoplasm • mitochondrion • cytosol • protein complex |
| Biological process | • DNA damage checkpoint • activation of MAPK activity • triglyceride metabolic process • epidermal growth factor receptor signaling pathway • axon guidance • brain development • heart development • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • hormone-mediated signaling pathway • cytokine-mediated signaling pathway • T cell costimulation • regulation of cell adhesion mediated by integrin • organ growth • peptidyl-tyrosine dephosphorylation • atrioventricular canal development • ERBB signaling pathway • regulation of multicellular organism growth • hormone metabolic process • glucose homeostasis • innate immune response • negative regulation of insulin secretion • regulation of protein export from nucleus • positive regulation of hormone secretion • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • phosphatidylinositol-mediated signaling • multicellular organismal reproductive process • genitalia development • inner ear development • leukocyte migration • negative regulation of cortisol secretion • negative regulation of growth hormone secretion • face morphogenesis • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway • positive regulation of glucose import in response to insulin stimulus |
| Sources: Amigo / QuickGO | |
112.86 – 112.95 Mb
121.13 – 121.19 Mb
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D) or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2.
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Read more about PTPN11: Structure and Function, Genetic Diseases Associated With PTPN11, Cancer Associated With PTPN11, Interactions
Other articles related to "ptpn11":
... Protein tyrosine phosphatase non-receptor 11 (PTPN11) interaction with GAB2 is part of the Ras pathway ... Mutations found in PTPN11 cause disruption in the binding to GAB2 which in turn impairs correct cellular growth ... with JMML show activating mutations in PTPN11 ...