PSHS is a four-letter acronym that may refer to:
- Plainfield South High School, in Plainfield, Illinois, United States
- Plano Senior High School, in Plano, Texas, United States
- Parkersburg South High School, in Parkersburg, West Virginia, United States
- Palm Springs High School, in Palm Springs, California
- Papillion South High School, in Papillion, Nebraska
- Poland Seminary High School, in Poland, Ohio
- Pittsford Sutherland High School, in Pittsford, New York, United States
- Parry Sound High School, in Parry Sound, Ontario, Canada
- Philippine Science High School System (various campuses)