Protein Kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction.

Read more about Protein KinaseChemical Activity, Regulation, Structure, Protein Kinase Groups, Serine/threonine-specific Protein Kinases, Tyrosine-specific Protein Kinases, Histidine-specific Protein Kinases, Mixed Kinases, Inhibitors, Kinase Assays and Profiling

Other articles related to "protein kinase, proteins, kinase, protein, kinases":

Skeletal Muscle - Signal Transduction Pathways
... These include pathways involved with the Ras/mitogen-activated protein kinase (MAPK), calcineurin, calcium/calmodulin-dependent protein kinase IV, and the peroxisome proliferator ... to the nucleus and leading to the activation of slow-type muscle proteins in cooperation with myocyte enhancer factor 2 (MEF2) proteins and other regulatory proteins ... Calcium-dependent Ca2+/calmodulin kinase activity is also upregulated by slow motor neuron activity, possibly because it amplifies the slow-type calcineurin-generated responses by promoting ...
... ChEMBL 1795198 GeneCards STRADA Gene Gene Ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP ...
... magnesium ion binding • p53 binding • protein serine/threonine kinase activity • protein binding • ATP binding • LRR domain binding ...
Cyclin H
2165 GeneCards CCNH Gene Gene Ontology Molecular function • protein kinase activity • protein binding • DNA-dependent ATPase activity • RNA polymerase II carboxy-terminal domain kinase activity • protein ... The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle ... Cyclins function as regulators of CDK kinases ...
Protein Kinase, AMP-activated, Alpha 1 - Interactions
... Protein kinase, AMP-activated, alpha 1 has been shown to interact with TSC2. ...

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