Protein Engineering

Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles.

There are two general strategies for protein engineering, rational design and directed evolution. These techniques are not mutually exclusive; researchers will often apply both. In the future, more detailed knowledge of protein structure and function, as well as advancements in high-throughput technology, may greatly expand the capabilities of protein engineering. Eventually, even unnatural amino acids may be incorporated thanks to a new method that allows the inclusion of novel amino acids in the genetic code.

Read more about Protein Engineering:  Rational Design of Proteins, Directed Evolution, Examples of Engineered Proteins

Other articles related to "protein engineering, proteins, protein, engineering":

Homologous Recombination - Technological Applications - Protein Engineering
... Protein engineering with homologous recombination develops chimeric proteins by swapping fragments between two parental proteins ... degree of sequence diversity while preserving a protein's ability to fold into its tertiary structure, or three-dimensional shape ... This stands in contrast to other protein engineering techniques, like random point mutagenesis, in which the probability of maintaining protein function declines exponentially with ...
Protein Engineering - Examples of Engineered Proteins
... Using computational methods, a protein with a novel fold has been designed, known as Top7, as well as sensors for unnatural molecules ... The engineering of fusion proteins has yielded rilonacept, a pharmaceutical which has secured FDA approval for the treatment of cryopyrin-associated periodic syndrome ... Iterative Protein Redesign and Optimization (IPRO) redesigns proteins to increase or give specificity to native or novel substrates and cofactors ...

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