Activation
PARs are activated by the action of serine proteases such as thrombin (acts on PARs 1, 3 and 4) and trypsin (PAR 2). These enzymes cleave the N-terminus of the receptor, which in turn acts as a tethered ligand. In the cleaved state, part of the receptor itself acts as the agonist, causing a physiological response.
Most of the PAR family act through the actions of G-proteins i (cAMP inhibitory), 12/13 (Raf/Ras activation) and q (calcium signalling) to cause cellular actions.
Read more about this topic: Protease-activated Receptor
Other articles related to "activation":
Snowmelt System - Activation Devices
... There are a number of activation devices used for snow melting applications ... High-end activation devices feature adjustable temperature trigger points, adjustable delay off cycle, and upgradeable remote activation ... The activation device enables the snowmelt system to run 100% automated ...
... There are a number of activation devices used for snow melting applications ... High-end activation devices feature adjustable temperature trigger points, adjustable delay off cycle, and upgradeable remote activation ... The activation device enables the snowmelt system to run 100% automated ...
Leveraging Sponsorships and Activation
... to exploit the commercial potential of the association between a sponsor and sponsee" while activation has been defined as those "communications that promote the engagement ...
... to exploit the commercial potential of the association between a sponsor and sponsee" while activation has been defined as those "communications that promote the engagement ...
LCD Classification - Activation
... One electro-optical effect with LCs requires a current through the LC-cell all other practiced electro-optical effects only require an electric field (without current) for alignment of the LC ... Electro-optical effects in Liquid Crystals LCs can be aligned by electric and magnetic fields electric field effects electro-hydrodynamic effects the electrical field aligns the liquid crystal no current is necessary (very low power required for operation) ...
... One electro-optical effect with LCs requires a current through the LC-cell all other practiced electro-optical effects only require an electric field (without current) for alignment of the LC ... Electro-optical effects in Liquid Crystals LCs can be aligned by electric and magnetic fields electric field effects electro-hydrodynamic effects the electrical field aligns the liquid crystal no current is necessary (very low power required for operation) ...
Side-by-side Assembly - Activation Contexts
... A manifest like the one above is parsed into an activation context by the SxS loader ... There is a stack of activation contexts for each thread or fiber ... It may be necessary for a library (DLL) to change its activation context, for example if it requires a specific version of another library for its own ...
... A manifest like the one above is parsed into an activation context by the SxS loader ... There is a stack of activation contexts for each thread or fiber ... It may be necessary for a library (DLL) to change its activation context, for example if it requires a specific version of another library for its own ...
Activation - Electrophysiology
... Activation refers to the opening of ion channels, i.e ... the conformational change that allows ions to pass ...
... Activation refers to the opening of ion channels, i.e ... the conformational change that allows ions to pass ...