Side Effects
Adverse effects include rash, myalgia, hypersensitivity reactions (fever, agranulocytosis), drug-induced lupus erythematosus (particularly in slow-acetylators), and proarrhythmic effects (e.g., torsades de pointes). Treatment with procainamide can cause antibody production against cellular components, accounting for the systemic lupus erythematosus-like adverse reactions. The Systemic Lupus Erythematosus reaction may present months or years after the initiation of the drug. A positive anti-histone antibody blood test may be useful in determining whether an SLE presentation is drug induced.
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