Peripheral Nerve Injury

Peripheral Nerve Injury

Peripheral nerve damage is categorized in the Seddon classification based on the extent of damage to both the nerve and the surrounding connective tissue since the nervous system is characterized by dependence of neurons on their supporting glia. Unlike in the central nervous system, regeneration in the peripheral nervous system is possible. The processes that occur in peripheral regeneration can be divided into the following major events: Wallerian degeneration, axon regeneration/growth, and nerve reinnervation. The events that occur in peripheral regeneration occur with respect to the axis of the nerve injury. The proximal stump refers to the end of the injured neuron that is still attached to the neuron cell body; it is the part that regenerates. The distal stump refers to the end of the injured neuron that is still attached to the end of the axon; it is the part that will degenerate but remains the area that the regenerating axon grows toward. The study of peripheral nerve injury began during the American Civil War and has since expanded to not only include to extensive characterization of the processes and factors that contribute to nerve regeneration and reinnervation, but also to determining therapies that enhance nerve regeneration such as biological conduits and administration of growth promoting molecules.

Read more about Peripheral Nerve InjuryTypes of Nerve Damage, Overview of Events in Peripheral Regeneration, Role of Schwann Cells, Role of Macrophages, Role of Neurotrophic Factors, Role of Neurite-Promoting Factors, Nerve Regeneration Therapies, See Also

Other articles related to "peripheral nerve injury, injury, nerve injury, nerve":

Neuralgia - Mechanisms - Peripheral Nerve Injury
... response to trauma can often be determined by the severity of the injury, classified by Seddon's classification ... In Seddon’s Classification, nerve injury is described as either neurapraxia, axonotmesis, or neurotmesis ... Following trauma to the nerve, a short onset of afferent impulses, termed “injury discharge”, occurs ...
Peripheral Nerve Injury - See Also
... Nerve Neurapraxia Axonotmesis Neurotmesis Nerve injury Neuroregeneration Wallerian degeneration Peripheral nerve injury classification ...

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