PDK3

Identifiers Symbol PDK3 External IDs OMIM: 602526 MGI: 2384308 HomoloGene: 55897 ChEMBL: 3893 GeneCards: PDK3 Gene EC number 2.7.11.2

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • pyruvate dehydrogenase (acetyl-transferring) kinase activity • protein binding • ATP binding
Cellular component	• mitochondrion • mitochondrial matrix
Biological process	• glucose metabolic process • pyruvate metabolic process • regulation of acetyl-CoA biosynthetic process from pyruvate • regulation of glucose metabolic process • peptidyl-serine phosphorylation • peroxisome proliferator activated receptor signaling pathway • small molecule metabolic process • cellular response to glucose stimulus • cellular response to fatty acid • hypoxia-inducible factor-1alpha signaling pathway • regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5165 236900 Ensembl ENSG00000067992 ENSMUSG00000035232 UniProt Q15120 Q922H2 RefSeq (mRNA) NM_001142386 NM_145630 RefSeq (protein) NP_001135858 NP_663605 Location (UCSC) Chr X:
24.48 – 24.56 Mb Chr X:
93.76 – 93.83 Mb PubMed search

Pyruvate dehydrogenase lipoamide kinase isozyme 3, mitochondrial is an enzyme that in humans is encoded by the PDK3 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.