OPL might be an acronym or abbreviation for:
- Open Publication License, often confused with the Open Content License
- Open programming language (formerly Organiser Programming Language)
- FM OPerator Type-L; a series of sound chips from Yamaha: YM3526 (OPL), YM3812 (OPL2), YMF262 (OPL3) and YMF278 (OPL4)
- Optique & Précision de Levallois, the optical company
- Outer plexiform layer, a layer of the Retina
- Oakville Public Library
- Oshawa Public Library
- Ottawa Public Library
- OPL Development Studio
- Optical path length
- Organisation du Peuple en Lutte (previously, Organisation Politique Lavalas): Struggling People's Organization (Haiti)
- One Person Library, also known as Solo librarianship.
- Oil Prospecting Lease
- Over Power Lines : as in Broadband Over Power Lines, a promising means to provide broadband over electrical lines
- One point lesson : is a high visibility communication tool used to deliver training to operator at machine place
- Online Player's League
- Ongamenet's Proleague
- Odisha Premier League
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