People
- Surname
- Addison Niles, American jurist
- Blair Niles, American author
- John Jacob Niles, American collector of folk music
- Hezekiah Niles, American newspaper editor
- Wendell Niles, radio announcer
- Fictional characters
- Niles the Butler, a character in the US television series The Nanny
- Niles Crane, a character in the US television series Frasier
- Niles Standish, a character in Crank Yankers
- Chief (comics), also known as Dr. Niles Caulder, a DC Comics character
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