- Ly49 (homodimers) — a relatively ancient, C-type lectin family receptor; are of multigenic presence in mice, while humans have only one pseudogenic Ly49; the receptor for classical (polymorphic) MHC I molecules.
- NCR (natural cytotoxicity receptors), upon stimulation, mediate NK killing and release of IFNϒ.
- CD94 : NKG2 (heterodimers) — a C-type lectin family receptor, conserved in both rodents and primates and identifies non-classical (also non-polymorphic) MHC I molecules like HLA-E. Expression of HLA-E at the cell surface is dependent on the presence of nonamer peptide epitope derived from the signal sequence of classical MHC class I molecules, which is generated by the sequential action of signal peptide peptidase and the proteasome. Though indirect, this is a way to survey the levels of classical (polymorphic) HLA molecules.
- CD16 (FcγIIIA) play a role in antibody-dependent cell-mediated cytotoxicity (ADCC), in particular they bind IgG.
Famous quotes containing the words receptors and/or activating:
“Our talk of external things, our very notion of things, is just a conceptual apparatus that helps us to foresee and control the triggerings of our sensory receptors in the light of previous triggering of our sensory receptors.”
—Willard Van Orman Quine (b. 1908)
“it is best then that the buried word remain buried for we were intended to appreciate only its fruits and not the secret principle activating them to know this would be to know too much. Meanwhile it is possible to know just enough, and this is all we were supposed to know, toward which we have been straining all our lives.”
—John Ashbery (b. 1927)