Myosin

Myosin

Myosins comprise a family of ATP-dependent motor proteins and are best known for their role in muscle contraction and their involvement in a wide range of other eukaryotic motility processes. They are responsible for actin-based motility. The term was originally used to describe a group of similar ATPases found in striated and smooth muscle cells. Following the discovery by Pollard and Korn of enzymes with myosin-like function in Acanthamoeba castellanii, a large number of divergent myosin genes have been discovered throughout eukaryotes. Thus, although myosin was originally thought to be restricted to muscle cells (hence, "myo"), there is no single "myosin" but rather a huge superfamily of genes whose protein products share the basic properties of actin binding, ATP hydrolysis (ATPase enzyme activity), and force transduction. Virtually all eukaryotic cells contain myosin isoforms. Some isoforms have specialized functions in certain cell types (such as muscle), while other isoforms are ubiquitous. The structure and function of myosin is strongly conserved across species, to the extent that rabbit muscle myosin II will bind to actin from an amoeba.

Read more about Myosin:  Nomenclature, Evolution, and The Family Tree, Genes in Humans, Paramyosin

Other articles related to "myosin":

Skeletal Muscle - Cellular Physiology and Contraction
... In addition to the actin and myosin components that constitute the sarcomere, skeletal muscle fibers also contain two other important regulatory proteins, troponin and tropomyosin, that are ... the movement of tropomyosin, subsequently exposing the myosin-binding sites on actin ... This allows for myosin and actin ATP-dependent cross-bridge cycling and shortening of the muscle ...
MYL6B
... of muscle Cellular component • cytosol • muscle myosin complex • myosin complex • unconventional myosin complex Biological process • muscle ... Myosin is a hexameric ATPase cellular motor protein ... This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue ...
MYL6
... actin-dependent ATPase activity Cellular component • cytosol • myosin complex • unconventional myosin complex Biological process • muscle contraction • axon guidance • skeletal ... Myosin is a hexameric ATPase cellular motor protein ... This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues ...
MYH3
... Myosin-3 is a protein that in humans is encoded by the MYH3 gene ... Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP ... Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains ...
Myosin - Paramyosin
... composed of an inner paramyosin core surrounded by myosin ... The myosin interacts with actin, resulting in fibre contraction ...