Modafinil - Side Effects

Side Effects

Common side effects of modafinil include:

  • Back pain
  • Headache
  • Nausea
  • Feeling nervous
  • Stuffy nose
  • Diarrhea
  • Feeling anxious
  • Dizziness
  • Upset stomach
  • Trouble sleeping

Serious side effects include:

  • Serious rash
  • Serious allergic reaction involving the liver or blood cells
  • Hives
  • Mouth sores
  • Blistering or peeling skin
  • Swelling of the face, eyes, lips, tongue, legs, or throat
  • Trouble swallowing or breathing
  • Fever
  • Shortness of breath
  • Yellowing of the skin or whites of the eyes
  • Dark urine

In 2007, the FDA ordered Cephalon to modify the Provigil leaflet in bold-face print of several serious and potentially fatal conditions attributed to modafinil use, including TEN, DRESS syndrome, and Stevens-Johnson Syndrome (SJS).

The long term safety and effectiveness of modafinil has not been determined.

Modafinil may have an adverse effect on hormonal contraceptives, lasting for a month after cessation of dosage.

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