List of Monoclonal Antibodies

This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies which are clones of a single parent cell. When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies.

The abbreviations in the column Type are as follows:

  • mab: whole monoclonal antibody
  • Fab: fragment, antigen-binding (one arm)
    • F(ab')2: fragment, antigen-binding, including hinge region (both arms)
    • Fab': fragment, antigen-binding, including hinge region (one arm)
  • Variable fragments:
    • scFv: single-chain variable fragment
    • di-scFv: dimeric single-chain variable fragment
    • sdAb: single-domain antibody
  • Bispecific monoclonal antibodies:
    • 3funct: trifunctional antibody
    • BiTE: bi-specific T-cell engager

This list includes approved and investigational drugs as well as drugs that have been withdrawn from market; consequently, the column Use does not necessarily indicate clinical usage.

Name Trade name Type Source Target Use
3F8 mab mouse GD2 neuroblastoma
8H9 mab mouse B7-H3 neuroblastoma, sarcoma, metastatic brain cancers
Abagovomab mab mouse CA-125 (imitation) ovarian cancer
Abciximab ReoPro Fab chimeric CD41 (integrin alpha-IIb) platelet aggregation inhibitor
Actoxumab mab human Clostridium difficile Clostridium difficile infection
Adalimumab Humira mab human TNF-α Rheumatoid arthritis, Crohn's Disease, Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis
Adecatumumab mab human EpCAM prostate and breast cancer
Afelimomab F(ab')2 mouse TNF-α sepsis
Afutuzumab mab humanized CD20 lymphoma
Alacizumab pegol F(ab')2 humanized VEGFR2 cancer
ALD518 ? humanized IL-6 rheumatoid arthritis
Alemtuzumab Campath, MabCampath mab humanized CD52 CLL, CTCL
Alirocumab mab human NARP-1 hypercholesterolemia
Altumomab pentetate Hybri-ceaker mab mouse CEA colorectal cancer (diagnosis)
Amatuximab mab chimeric MORAb-009 cancer
Anatumomab mafenatox Fab mouse TAG-72 non-small cell lung carcinoma
Anrukinzumab (= IMA-638) mab humanized IL-13 ?
Apolizumab mab humanized HLA-DR ? hematological cancers
Arcitumomab CEA-Scan Fab' mouse CEA gastrointestinal cancers (diagnosis)
Aselizumab mab humanized L-selectin (CD62L) severely injured patients
Atinumab mab human RTN4 ?
Atlizumab (= tocilizumab) Actemra, RoActemra mab humanized IL-6 receptor rheumatoid arthritis
Atorolimumab mab human Rhesus factor hemolytic disease of the newborn
Bapineuzumab mab humanized beta amyloid Alzheimer's disease
Basiliximab Simulect mab chimeric CD25 (α chain of IL-2 receptor) prevention of organ transplant rejections
Bavituximab mab chimeric phosphatidylserine cancer, viral infections
Bectumomab LymphoScan Fab' mouse CD22 non-Hodgkin's lymphoma (detection)
Belimumab Benlysta, LymphoStat-B mab human BAFF non-Hodgkin lymphoma etc.
Benralizumab mab humanized CD125 asthma
Bertilimumab mab human CCL11 (eotaxin-1) severe allergic disorders
Besilesomab Scintimun mab mouse CEA-related antigen inflammatory lesions and metastases (detection)
Bevacizumab Avastin mab humanized VEGF-A metastatic cancer
Bezlotoxumab mab human Clostridium difficile Clostridium difficile infection
Biciromab FibriScint Fab' mouse fibrin II, beta chain thromboembolism (diagnosis)
Bimagrumab mab human ACVR2B myostatin inhibitor
Bivatuzumab mertansine mab humanized CD44 v6 squamous cell carcinoma
Blinatumomab BiTE mouse CD19 cancer
Blosozumab mab humanized SOST osteoporosis
Brentuximab vedotin mab chimeric CD30 (TNFRSF8) hematologic cancers
Briakinumab mab human IL-12, IL-23 psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis
Brodalumab mab human IL-17 inflammatory diseases
Canakinumab Ilaris mab human IL-1? rheumatoid arthritis
Cantuzumab mertansine mab humanized mucin CanAg colorectal cancer etc.
Cantuzumab ravtansine mab humanized MUC1 cancers
Caplacizumab mab humanized VWF ?
Capromab pendetide Prostascint mab mouse prostatic carcinoma cells prostate cancer (detection)
Carlumab mab human CNTO888 oncology/immune indications
Catumaxomab Removab 3funct rat/mouse hybrid EpCAM, CD3 ovarian cancer, malignant ascites, gastric cancer
CC49 mab mouse TAG-72 tumor detection
Cedelizumab mab humanized CD4 prevention of organ transplant rejections, treatment of autoimmune diseases
Certolizumab pegol Cimzia Fab' humanized TNF-α Crohn's disease
Cetuximab Erbitux mab chimeric EGFR metastatic colorectal cancer and head and neck cancer
Ch.14.18 mab chimeric ??? neuroblastoma
Citatuzumab bogatox Fab humanized EpCAM ovarian cancer and other solid tumors
Cixutumumab mab human IGF-1 receptor solid tumors
Clazakizumab mab humanized Oryctolagus cuniculus rheumatoid arthritis
Clenoliximab mab chimeric CD4 rheumatoid arthritis
Clivatuzumab tetraxetan hPAM4-Cide mab humanized MUC1 pancreatic cancer
Conatumumab mab human TRAIL-R2 cancer
Concizumab mab humanized TFPI bleeding
Crenezumab mab humanized MABT5102A Alzheimer's disease
CR6261 mab human Influenza A hemagglutinin infectious disease/influenza A
Dacetuzumab mab humanized CD40 hematologic cancers
Daclizumab Zenapax mab humanized CD25 (α chain of IL-2 receptor) prevention of organ transplant rejections
Dalotuzumab mab humanized insulin-like growth factor I receptor cancer etc.
Daratumumab mab human CD38 (cyclic ADP ribose hydrolase) ?
Demcizumab mab humanized DLL4 cancer
Denosumab Prolia mab human RANKL osteoporosis, bone metastases etc.
Detumomab mab mouse B-lymphoma cell lymphoma
Dorlimomab aritox F(ab')2 mouse ? ?
Drozitumab mab human DR5 cancer etc.
Duligotumab mab human HER3 ?
Dupilumab mab human IL4 atopic diseases
Dusigitumab mab human ILGF2 cancer
Ecromeximab mab chimeric GD3 ganglioside malignant melanoma
Eculizumab Soliris mab humanized C5 paroxysmal nocturnal hemoglobinuria
Edobacomab mab mouse endotoxin sepsis caused by Gram-negative bacteria
Edrecolomab Panorex mab mouse EpCAM colorectal carcinoma
Efalizumab Raptiva mab humanized LFA-1 (CD11a) psoriasis (blocks T-cell migration)
Efungumab Mycograb scFv human Hsp90 invasive Candida infection
Elotuzumab mab humanized SLAMF7 multiple myeloma
Elsilimomab mab mouse IL-6 ?
Enavatuzumab mab humanized PDL192 cancer etc.
Enlimomab pegol mab mouse ICAM-1 (CD54) ?
Enokizumab mab humanized MEDI-528 asthma
Enoticumab mab human DLL4 ?
Ensituximab mab chimeric NPC-1C cancer
Epitumomab cituxetan mab mouse episialin ?
Epratuzumab mab humanized CD22 cancer, SLE
Erlizumab F(ab')2 humanized ITGB2 (CD18) heart attack, stroke, traumatic shock
Ertumaxomab Rexomun 3funct rat/mouse hybrid HER2/neu, CD3 breast cancer etc.
Etaracizumab Abegrin mab humanized integrin αvβ3 melanoma, prostate cancer, ovarian cancer etc.
Etrolizumab mab humanized rhuMAb β7 inflammatory bowel disease
Evolocumab mab human PCSK9 hypocholesterolemia
Exbivirumab mab human hepatitis B surface antigen hepatitis B
Fanolesomab NeutroSpec mab mouse CD15 appendicitis (diagnosis)
Faralimomab mab mouse interferon receptor ?
Farletuzumab mab humanized folate receptor 1 ovarian cancer
Fasinumab mab human HNGF ?
FBTA05 Lymphomun 3funct rat/mouse hybrid CD20 chronic lymphocytic leukaemia
Felvizumab mab humanized respiratory syncytial virus respiratory syncytial virus infection
Fezakinumab mab human IL-22 rheumatoid arthritis, psoriasis
Ficlatuzumab mab humanized SCH 900105 cancer etc.
Figitumumab mab human IGF-1 receptor adrenocortical carcinoma, non-small cell lung carcinoma etc.
Flanvotumab mab human glycoprotein 75 melanoma
Fontolizumab HuZAF mab humanized IFN-γ Crohn's disease etc.
Foralumab mab human CD3 epsilon ?
Foravirumab mab human rabies virus glycoprotein rabies (prophylaxis)
Fresolimumab mab human TGF-β idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer
Fulranumab mab human NGF pain
Futuximab mab chimeric EGFR ?
Galiximab mab chimeric CD80 B-cell lymphoma
Ganitumab mab human IGF-I cancer
Gantenerumab mab human beta amyloid Alzheimer's disease
Gavilimomab mab mouse CD147 (basigin) graft versus host disease
Gemtuzumab ozogamicin Mylotarg mab humanized CD33 acute myelogenous leukemia
Gevokizumab mab humanized IL-1β diabetes etc.
Girentuximab Rencarex mab chimeric carbonic anhydrase 9 (CA-IX) clear cell renal cell carcinoma
Glembatumumab vedotin mab human GPNMB melanoma, breast cancer
Golimumab Simponi mab human TNF-α rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis
Gomiliximab mab chimeric CD23 (IgE receptor) allergic asthma
GS6624 mab ? ? idiopathic pulmonary fibrosis and solid tumors
Ibalizumab mab humanized CD4 HIV infection
Ibritumomab tiuxetan Zevalin mab mouse CD20 non-Hodgkin's lymphoma
Icrucumab mab human VEGFR-1 cancer etc.
Igovomab Indimacis-125 F(ab')2 mouse CA-125 ovarian cancer (diagnosis)
Imciromab Myoscint mab mouse cardiac myosin cardiac imaging
Imgatuzumab mab humanized EGFR cancer
Inclacumab mab human selectin P ?
Indatuximab ravtansine mab chimeric SDC1 cancer
Infliximab Remicade mab chimeric TNF-α rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis
Intetumumab mab human CD51 solid tumors (prostate cancer, melanoma)
Inolimomab mab mouse CD25 (α chain of IL-2 receptor) graft versus host disease
Inotuzumab ozogamicin mab humanized CD22 cancer
Ipilimumab Yervoy mab human CD152 melanoma
Iratumumab mab human CD30 (TNFRSF8) Hodgkin's lymphoma
Itolizumab mab humanized CD6 ?
Ixekizumab mab humanized IL-17A autoimmune diseases
Keliximab mab chimeric CD4 chronic asthma
Labetuzumab CEA-Cide mab humanized CEA colorectal cancer
Lampalizumab mab humanized CFD ?
Lebrikizumab mab humanized IL-13 asthma
Lemalesomab mab mouse NCA-90 (granulocyte antigen) diagnostic agent
Lerdelimumab mab human TGF beta 2 reduction of scarring after glaucoma surgery
Lexatumumab mab human TRAIL-R2 cancer
Libivirumab mab human hepatitis B surface antigen hepatitis B
Ligelizumab mab humanized IGHE ?
Lintuzumab mab humanized CD33 cancer
Lirilumab mab human KIR2D ?
Lodelcizumab mab humanized PCSK9 hypercholesterolemia
Lorvotuzumab mertansine mab humanized CD56 cancer
Lucatumumab mab human CD40 multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma
Lumiliximab mab chimeric CD23 (IgE receptor) chronic lymphocytic leukemia
Mapatumumab mab human TRAIL-R1 cancer
Maslimomab ? mouse T-cell receptor ?
Mavrilimumab mab human CAM-3001 rheumatoid arthritis
Matuzumab mab humanized EGFR colorectal, lung and stomach cancer
Mepolizumab Bosatria mab humanized IL-5 asthma and white blood cell diseases
Metelimumab mab human TGF beta 1 systemic scleroderma
Milatuzumab mab humanized CD74 multiple myeloma and other hematological malignancies
Minretumomab mab mouse TAG-72 ?
Mitumomab mab mouse GD3 ganglioside small cell lung carcinoma
Mogamulizumab mab humanized CCR4 cancer
Morolimumab mab human Rhesus factor ?
Motavizumab Numax mab humanized respiratory syncytial virus respiratory syncytial virus (prevention)
Moxetumomab pasudotox mab mouse CD22 cancer
Muromonab-CD3 Orthoclone OKT3 mab mouse CD3 prevention of organ transplant rejections
Nacolomab tafenatox Fab mouse C242 antigen colorectal cancer
Namilumab mab human CSF2 ?
Naptumomab estafenatox Fab mouse 5T4 non-small cell lung carcinoma, renal cell carcinoma
Narnatumab mab human RON cancer
Natalizumab Tysabri mab humanized integrin α4 multiple sclerosis, Crohn's disease
Nebacumab mab human endotoxin sepsis
Necitumumab mab human EGFR non-small cell lung carcinoma
Nerelimomab mab mouse TNF-α ?
Nesvacumab mab human angiopoietin 2 cancer
Nimotuzumab Theracim, Theraloc mab humanized EGFR squamous cell carcinoma, head and neck cancer, nasopharyngeal cancer, glioma
Nivolumab mab human IgG4 cancer
Nofetumomab merpentan Verluma Fab mouse ? cancer (diagnosis)
Ocaratuzumab mab humanized CD20 cancer
Ocrelizumab mab humanized CD20 rheumatoid arthritis, lupus erythematosus etc.
Odulimomab mab mouse LFA-1 (CD11a) prevention of organ transplant rejections, immunological diseases
Ofatumumab Arzerra mab human CD20 chronic lymphocytic leukemia etc.
Olaratumab mab human PDGF-R α cancer
Olokizumab mab humanized IL6 ?
Omalizumab Xolair mab humanized IgE Fc region allergic asthma
Onartuzumab mab humanized human scatter factor receptor kinase cancer
Oportuzumab monatox scFv humanized EpCAM cancer
Oregovomab OvaRex mab mouse CA-125 ovarian cancer
Orticumab mab human oxLDL ?
Otelixizumab mab chimeric/humanized CD3 diabetes mellitus type 1
Oxelumab mab human OX-40 asthma
Ozanezumab mab humanized NOGO-A ALS and multiple sclerosis
Ozoralizumab mab humanized Lama glama inflammation
Pagibaximab mab chimeric lipoteichoic acid sepsis (Staphylococcus)
Palivizumab Synagis, Abbosynagis mab humanized F protein of respiratory syncytial virus respiratory syncytial virus (prevention)
Panitumumab Vectibix mab human EGFR colorectal cancer
Panobacumab mab human Pseudomonas aeruginosa Pseudomonas aeruginosa infection
Parsatuzumab mab human EGFL7 cancer
Pascolizumab mab humanized IL-4 asthma
Pateclizumab mab humanized LTA TNF
Patritumab mab human HER3 cancer
Pemtumomab Theragyn ? mouse MUC1 cancer
Perakizumab mab humanized IL17A ?
Pertuzumab Omnitarg mab humanized HER2/neu cancer
Pexelizumab scFv humanized C5 reduction of side effects of cardiac surgery
Pidilizumab mab humanized PD-1 cancer and infectious diseases
Pinatuzumab vedotin mab humanized CD22 cancer
Pintumomab mab mouse adenocarcinoma antigen adenocarcinoma (imaging)
Placulumab mab human human TNF ?
Polatuzumab vedotin mab humanized CD79B ?
Ponezumab mab humanized human beta-amyloid Alzheimer's disease
Priliximab mab chimeric CD4 Crohn's disease, multiple sclerosis
Pritoxaximab mab chimeric E. coli shiga toxin type-1 ?
Pritumumab mab human vimentin brain cancer
PRO 140 ? humanized CCR5 HIV infection
Quilizumab mab humanized IGHE ?
Racotumomab mab mouse N-glycolylneuraminic acid cancer
Radretumab mab human fibronectin extra domain-B cancer
Rafivirumab mab human rabies virus glycoprotein rabies (prophylaxis)
Ramucirumab mab human VEGFR2 solid tumors
Ranibizumab Lucentis Fab humanized VEGF-A macular degeneration (wet form)
Raxibacumab mab human anthrax toxin, protective antigen anthrax (prophylaxis and treatment)
Regavirumab mab human cytomegalovirus glycoprotein B cytomegalovirus infection
Reslizumab mab humanized IL-5 inflammations of the airways, skin and gastrointestinal tract
Rilotumumab mab human HGF solid tumors
Rituximab MabThera, Rituxan mab chimeric CD20 lymphomas, leukemias, some autoimmune disorders
Robatumumab mab human IGF-1 receptor cancer
Roledumab mab human RHD ?
Romosozumab mab humanized scleroscin osteoporosis
Rontalizumab mab humanized IFN-α systemic lupus erythematosus
Rovelizumab LeukArrest mab humanized CD11, CD18 haemorrhagic shock etc.
Ruplizumab Antova mab humanized CD154 (CD40L) rheumatic diseases
Samalizumab mab humanized CD200 cancer
Sarilumab mab human IL6 rheumatoid arthritis, ankylosing spondylitis
Satumomab pendetide mab mouse TAG-72 cancer (diagnosis)
Secukinumab mab human IL-17A uveitis, rheumatoid arthritis psoriasis
Seribantumab mab human ERBB3 cancer
Setoxaximab mab chimeric E. coli shiga toxin type-1 ?
Sevirumab ? human cytomegalovirus cytomegalovirus infection
Sibrotuzumab mab humanized FAP cancer
Sifalimumab mab humanized IFN-α SLE, dermatomyositis, polymyositis
Siltuximab mab chimeric IL-6 cancer
Simtuzumab mab humanized LOXL2 ?
Siplizumab mab humanized CD2 psoriasis, graft-versus-host disease (prevention)
Sirukumab mab human IL-6 rheumatoid arthritis
Solanezumab mab humanized beta amyloid Alzheimer's disease
Solitomab mab mouse EPCAM ?
Sonepcizumab ? humanized sphingosine-1-phosphate choroidal and retinal neovascularization
Sontuzumab mab humanized episialin ?
Stamulumab mab human myostatin muscular dystrophy
Sulesomab LeukoScan Fab' mouse NCA-90 (granulocyte antigen) osteomyelitis (imaging)
Suvizumab mab humanized HIV-1 viral infections
Tabalumab mab human BAFF B-cell cancers
Tacatuzumab tetraxetan AFP-Cide mab humanized alpha-fetoprotein cancer
Tadocizumab Fab humanized integrin αIIbβ3 percutaneous coronary intervention
Talizumab mab humanized IgE allergic reaction
Tanezumab mab humanized NGF pain
Taplitumomab paptox mab mouse CD19 cancer
Tefibazumab Aurexis mab humanized clumping factor A Staphylococcus aureus infection
Telimomab aritox Fab mouse ? ?
Tenatumomab mab mouse tenascin C cancer
Teneliximab mab chimeric CD40 ?
Teplizumab mab humanized CD3 diabetes mellitus type 1
Teprotumumab mab human CD221 hematologic tumors
TGN1412 ? humanized CD28 chronic lymphocytic leukemia, rheumatoid arthritis
Ticilimumab (= tremelimumab) mab human CTLA-4 cancer
Tildrakizumab mab humanized IL23 immunologically mediated inflammatory disorders
Tigatuzumab mab humanized TRAIL-R2 cancer
TNX-650 ? humanized IL-13 Hodgkin's lymphoma
Tocilizumab (= atlizumab) Actemra, RoActemra mab humanized IL-6 receptor rheumatoid arthritis
Toralizumab mab humanized CD154 (CD40L) rheumatoid arthritis, lupus nephritis etc.
Tositumomab Bexxar ? mouse CD20 follicular lymphoma
Tralokinumab mab human IL-13 asthma etc.
Trastuzumab Herceptin mab humanized HER2/neu breast cancer
TRBS07 Ektomab 3funct ? GD2 melanoma
Tregalizumab mab humanized CD4 ?
Tremelimumab mab human CTLA-4 cancer
Tucotuzumab celmoleukin mab humanized EpCAM cancer
Tuvirumab ? human hepatitis B virus chronic hepatitis B
Ublituximab mab chimeric MS4A1 cancer
Urelumab mab human 4-1BB cancer etc.
Urtoxazumab mab humanized Escherichia coli diarrhoea caused by E. coli
Ustekinumab Stelara mab human IL-12, IL-23 multiple sclerosis, psoriasis, psoriatic arthritis
Vapaliximab mab chimeric AOC3 (VAP-1) ?
Vatelizumab mab humanized ITGA2 ?
Vedolizumab mab humanized integrin α4β7 Crohn's disease, ulcerative colitis
Veltuzumab mab humanized CD20 non-Hodgkin's lymphoma
Vepalimomab mab mouse AOC3 (VAP-1) inflammation
Vesencumab mab human NRP1 ?
Visilizumab Nuvion mab humanized CD3 Crohn's disease, ulcerative colitis
Volociximab mab chimeric integrin α5β1 solid tumors
Vorsetuzumab mafodotin mab humanized cancer
Votumumab HumaSPECT mab human tumor antigen CTAA16.88 colorectal tumors
Zalutumumab HuMax-EGFr mab human EGFR squamous cell carcinoma of the head and neck
Zanolimumab HuMax-CD4 mab human CD4 rheumatoid arthritis, psoriasis, T-cell lymphoma
Zatuximab mab chimeric HER1 cancer
Ziralimumab mab human CD147 (basigin) ?
Zolimomab aritox mab mouse CD5 systemic lupus erythematosus, graft-versus-host disease

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