| Gene Ontology | |
|---|---|
| Molecular function | • actin binding • calcium ion binding • identical protein binding • actin filament binding |
| Cellular component | • phagocytic cup • cytoplasm • cytosol • actin filament • plasma membrane • actin cytoskeleton • cell junction • ruffle membrane |
| Biological process | • T cell activation involved in immune response • organ regeneration • regulation of intracellular protein transport • actin filament bundle assembly |
| Sources: Amigo / QuickGO | |
46.7 – 46.79 Mb
75.13 – 75.23 Mb
Plastin-2 is a protein that in humans is encoded by the LCP1 gene.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.