LCN2

LCN2

Identifiers Symbols LCN2; 24p3; MSFI; NGAL External IDs OMIM: 600181 MGI: 96757 HomoloGene: 4064 ChEMBL: 1741308 GeneCards: LCN2 Gene

Gene Ontology
Molecular function	• protease binding • transporter activity • iron ion binding • small molecule binding • protein homodimerization activity
Cellular component	• extracellular region • extracellular space • cytoplasm • cytosol
Biological process	• ion transport • apoptotic process • response to virus • response to herbicide • positive regulation of gene expression • siderophore transport • positive regulation of cell projection organization • cellular response to nutrient levels • response to drug • regulation of apoptotic process • innate immune response • protein homotrimerization • cellular response to hydrogen peroxide • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to tumor necrosis factor
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3934 16819 Ensembl ENSG00000148346 ENSMUSG00000026822 UniProt P80188 P11672 RefSeq (mRNA) NM_005564 NM_008491 RefSeq (protein) NP_005555 NP_032517 Location (UCSC) Chr 9:
130.91 – 130.92 Mb Chr 2:
32.38 – 32.39 Mb PubMed search

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein that in humans is encoded by the LCN2 gene. NGAL is involved in innate immunity by sequestrating iron that in turn limits bacterial growth. It is expressed in neutrophils and in low levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. NGAL is used as a biomarker of kidney function.