Kieffer may mean:
- Aldine Silliman Kieffer (1840-1904), American music writer
- Charles Kieffer, American athlete
- Eduardo Gudiño Kieffer (1935-2002), Argentine writer
- Guy-André Kieffer, French-Canadian journalist
- Jean-Jacques Kieffer, French entomologist
- Oliver Kieffer (b. 1979), French volleyball player
- Philippe Kieffer (1899-1962), French naval officer
- Susan Kieffer (b. 1942), American geologist
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