Journal of Molecular Biology - Notable Articles

Notable Articles

Some of the most highly cited articles that have appeared in the Journal of Molecular Biology since its inception in April 1959 include:

  • "On the nature of allosteric transitions: a plausible model," in 1965, in which Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux presented the MWC model, that explained the cooperativity exhibited by allosteric proteins, such as hemoglobin.
  • "Detection of Specific Sequences Among DNA Fragments Separated by Gel-Electrophoresis," in 1975, in which Edwin Southern presented the first description of nucleic acid blotting, a technique that revolutionized the field of molecular biology.
  • "Identification of Common Molecular Subsequences," in 1981, in which the Smith–Waterman algorithm for determining the degree of homology of DNA, RNA, or protein sequences was first described.
  • "Basic Local Alignment Search Tool," in 1990, in which the nucleic acid and protein homology search algorithm known as BLAST was originally described.

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