The complement system is a biochemical cascade of the immune system that helps, or “complements”, the ability of antibodies to clear pathogens or mark them for destruction by other cells. The cascade is composed of many plasma proteins, synthesised in the liver, primarily by hepatocytes. The proteins work together to:
- trigger the recruitment of inflammatory cells.
- "tag" pathogens for destruction by other cells by opsonizing, or coating, the surface of the pathogen.
- forming holes in the plasma membrane of the pathogen, resulting in cytolysis of the pathogen cell, causing the death of the pathogen.
- rid the body of neutralised antigen-antibody complexes.
Elements of the complement cascade can be found in many nonmammalian species including plants, birds, fish and some species of invertebrates.
Read more about this topic: Innate Immune System
Other articles related to "system, complement system, complement":
... Produced by Description Bradykinin Kinin system A vasoactive protein which is able to induce vasodilation, increase vascular permeability, cause smooth muscle contraction, and induce pain ... C3 Complement system Cleaves to produce C3a and C3b ... C5a Complement system Stimulates histamine release by mast cells, thereby producing vasodilation ...
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... Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins ... can be divided into two categories Disorders of the proteins that act to inhibit the complement system (such as C1-inhibitor) can lead to an overactive response ... of the proteins that act to activate the complement system (such as C3) can lead to an underactive response, causing greater susceptibility to infections ...
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