Hypersensitivity - Coombs and Gell Classification | Coombs Gell Classification

Coombs and Gell Classification

**Comparison of hypersensitivity types**
Type	Alternative names	Often mentioned disorders	Mediators
I	Allergy (immediate)	Atopy Anaphylaxis Asthma	IgE and IgG4
II	Cytotoxic, antibody-dependent	Autoimmune hemolytic anemia Thrombocytopenia Erythroblastosis fetalis Goodpasture's syndrome Membranous nephropathy Graves' disease see type V explanation below Myasthenia Gravis see type V explanation below	IgM or IgG (Complement)
III	Immune complex disease	Serum sickness Arthus reaction Rheumatoid arthritis Post streptococcal glomerulonephritis lupus Nephritis Systemic lupus erythematosus (SLE) Extrinsic allergic alveolitis (Hypersensitivity pneumonitis)	IgG (Complement)
IV	Delayed-type hypersensitivity (DTH), cell-mediated immune memory response, antibody-independent	Contact dermatitis Mantoux test Chronic transplant rejection Multiple sclerosis	T-cells
V	Autoimmune disease, receptor mediated (see below)	Graves' disease Myasthenia Gravis	IgM or IgG (Complement)