Hydrophilic interaction chromatography (or hydrophilic interaction liquid chromatography, HILIC) is a version of partition chromatography which occupies the opposite end of the partition spectrum from reversed phase liquid chromatography. Both are distinct from normal phase liquid chromatography in that water is part of the mobile phase, and thus not adsorption chromatography. The name was suggested by Dr. Andrew Alpert in his 1990 paper on the subject. He described the chromatographic mechanism for it as liquid-liquid partition chromatography where analytes elute in order of increasing polarity, a conclusion supported by a review and re-evaluation of published data.
Read more about Hydrophilic Interaction Chromatography: Surface, Mobile Phase, Additives, Uses, Choice of PH, ERLIC, Cationic EHILIC, Anionic EHILIC
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