HPC may refer to:
- Handheld PC
- Hasty Pudding cipher
- Health Professions Council
- Hemangiopericytoma
- Hematopoietic progenitor cell
- High-performance computing
- Windows HPC Server 2008, an operating system for high-performance computing by Microsoft
- History of presenting complaint, often found written in patients' medical record
- Hmar Peoples Convention, a separatist political party in the Indian state of Mizoram
- HousePriceCrash
- Hydrometeorological Prediction Center
- Hydroxypropyl cellulose
- High Priority Corridor, component of the Intermodal Surface Transportation Efficiency Act