Heliotrope may refer to:
- Natural science
- Heliotropium, a genus of flowering plants
- A plant that exhibits heliotropism, diurnal motion in response to the sun's movement
- Heliotrope (mineral)
- Media and entertainment
- "Heliotrope" (song), by At the Drive-In
- Heliotrope (artist), Danish record producer
- Heliotrope Studios, a video game developer
- "Heliotrope", a song by Robyn Hitchcock on the album Moss Elixir
- "Heliotrope", a story collection by Justina Robson
- Other uses
- Heliotrope (color)
- Heliotrope (instrument), a surveying tool
- Heliotrope (building), a rotating home built by Rolf Disch
- A distinctive rash associated with juvenile dermatomyositis