Hasselbalch

Protein P Ka Calculations - PKa Calculation Methods - Determining PKa Values From Titration Curves or Free Energy Calculations
... The pKa1/2 is equal to the Henderson-Hasselbalch pKa pKaHH if the titration curve follows the Henderson-Hasselbalch equation ... pKa calculation methods silently assume that all titration curves are Henderson-Hasselbalch shaped, and pKa values in pKa calculation programs are therefore often determined in this way ... In contrast, the Henderson-Hasselbalch pKa value can be computed from the protonation free energy via and is thus in turn related to the protonation free energy of the ...

Karl Albert Hasselbalch
... Karl Albert Hasselbalch ( 1 November 1874, Aastrup, Denmark - 19 September 1962) was a physician and chemist ... Henderson to logarithmic form, which is now known as the Henderson-Hasselbalch equation ... Authority control VIAF 73487542 Persondata Name Hasselbalch, Karl Albert Alternative names Short description Date of birth 1 November 1874 Place of birth Date of death 19 September 1962 Place of death ...

Implicit Solvation - Problems and Limitations - Treatment of Ionization Effects
... to 7 kcal/mol for Asp, Glu, Lys, and Arg amino acid residues, according to the Henderson-Hasselbalch equation, ΔG=2.3RT(pH-pK) ... was treated using different solvation parameters for charged atoms or Henderson-Hasselbalch equation with some modifications ... Thus, the energetic penalties can be overestimated even using the Henderson-Hasselbalch equation ...