Growth Factor

A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.

Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.

They often promote cell differentiation and maturation, which varies between growth factors. For example, bone morphogenic proteins stimulate bone cell differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis).

Read more about Growth Factor:  Growth Factors Versus Cytokines, Classes of Growth Factors, Uses in Medicine

Other articles related to "growth factors, growth factor, factor, growth, factors":

SULF1 - Role in Cancer - Hepatocellular Carcinoma
... sustained activation of ERK1/2 and c-met by the heparin binding growth factors (HB-GF), fibroblast growth factor (FGF) and hepatocyte growth factor (HGF ... As a review, HGF, or scatter factor, activates its receptor c-Met which activates mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK ... The HGF/c-Met axis mediates the invasive growth phenotype necessary for metastasis through coordination of cell motility and degradation of extracellular ...
Signal Transducing Adaptor Molecule
... protein transport • signal transduction • epidermal growth factor receptor signaling pathway • cellular membrane organization • endosomal ... HGS/HRS (hepatocyte growth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein ...
CYR61 - Gene Structure and Regulation
... with binding sites for many transcription factors including AP1, ATF, E2F, HNF3b, NF1, NFκB, SP1, and SRF, and 2 poly(CA) stretches that may form Z-DNA structure ... range of environmental perturbations, including stimulation by platelet-derived growth factor and basic fibroblast growth factor, transforming growth factor β1 (TGF-β1 ...
SPRY2 - Function
... activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles ... dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two ... is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling ...
Growth Factor - Uses in Medicine
... For the last two decades, growth factors have been increasingly used in the treatment of hematologic and oncologic diseases and cardiovascular diseases like neutropenia myelodysplastic ...

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