Estrogen Receptor
Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 (GPER), which is a G protein-coupled receptor. This article refers to the former (ER).
Once activated by estrogen, the estrogen receptor is able to bind to DNA and regulate the activity of many different genes (i.e. it is a DNA-binding transcription factor). However, it also has additional functions independent of DNA binding.
Read more about Estrogen Receptor: Proteomics, Genetics, Distribution, Binding and Functional Selectivity, Signal Transduction, Research History
Other articles related to "estrogen receptor, receptor, estrogen, estrogen receptors":
... Selective estrogen receptor modulators (SERMs) are a class of compounds that act on the estrogen receptor ... A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues ...
... Selective estrogen receptor modulators (SERMs) are a commonly used adjuvant therapy in estrogen-receptor positive (ERα+) breast cancer and a preventive treatment for women at high risk of the disease ... These include Loss of estrogen receptor alpha (ERα) Although this may be a mechanism of resistance in a minority of women, most ERα+ tumors that become resistant to SERMS remain ER ...
... The commercial test is marketed for use in breast cancer irrespective of estrogen receptor (ER) status ... have the following characteristics stage 1 or 2, tumor size less than 5.0 cm, estrogen receptor positive (ER+) or estrogen receptor negative (ER-) ...
... Similarly to SERMs, phyto-SERMs act on the estrogen receptor in a selective manner, either as agonists, or as antagonists, thereby granting the possibility to selectively ... coregulators in different tissues which interact with the estrogen receptor ... appear to be somewhat selective in binding for the estrogen receptor beta (ERβ) compared to the estrogen receptor alpha (ERα) paralog ...
... Estrogen receptors were first identified by Elwood V ... The gene for a second estrogen receptor (ERβ) was identified in 1996 by Kuiper et al ...
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