Ionic Bonds
Mainly occur through attractions between opposite charges. For example, between protonated amino (on salbutamol) or quaternary ammonium (e.g. acetylcholine), and the dissociated carboxylic acid group. Similarly, the dissociated carboxylic acid group on the drug can bind with amino groups on the receptor.
This type of bonds are very strong, and varies with so it could act over large distances.
Cation-π interactions can also be classified as ionic bonding. This occurs when a cation, e.g. acetylcholine, interacts with the negative π bonds on an aromatic group of the receptor.
Ion-dipole and dipole-dipole bonds have similar interactions, but are more complicated and are weaker than ionic bonds.
Read more about this topic: Drug Action, Short Note On Receptors
Other articles related to "ionic bonds":
... When the energy difference between the atomic orbitals of two atoms is quite large, one atom's orbitals contribute almost entirely to the bonding orbitals, and the others atom’s orbitals contribute almost entirely to the antibonding orbitals ... Thus, the situation is effectively that some electrons have been transferred from one atom to the other ...
... Electric force which normally holds salt crystals together by way of ionic bonds is weakened in the presence of water allowing ions to separate from the crystal and spread ... weak electric force prevents them from forming stable ionic bonds with phosphates and precipitating out of solution ... groups and any positive ions present in solution becomes strong enough to form stable ionic bonds and DNA precipitation ...
Famous quotes containing the word bonds:
“For, truly speaking, whoever provokes me to a good act or thought has given me a pledge of his fidelity to virtue,—he has come under the bonds to adhere to that cause to which we are jointly attached.”
—Ralph Waldo Emerson (1803–1882)