Drug Action - Short Note On Receptors - Ionic Bonds

Ionic Bonds

Mainly occur through attractions between opposite charges. For example, between protonated amino (on salbutamol) or quaternary ammonium (e.g. acetylcholine), and the dissociated carboxylic acid group. Similarly, the dissociated carboxylic acid group on the drug can bind with amino groups on the receptor.

This type of bonds are very strong, and varies with so it could act over large distances.

Cation-π interactions can also be classified as ionic bonding. This occurs when a cation, e.g. acetylcholine, interacts with the negative π bonds on an aromatic group of the receptor.

Ion-dipole and dipole-dipole bonds have similar interactions, but are more complicated and are weaker than ionic bonds.

Read more about this topic:  Drug Action, Short Note On Receptors

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