Ionic Bonds
Mainly occur through attractions between opposite charges. For example, between protonated amino (on salbutamol) or quaternary ammonium (e.g. acetylcholine), and the dissociated carboxylic acid group. Similarly, the dissociated carboxylic acid group on the drug can bind with amino groups on the receptor.
This type of bonds are very strong, and varies with so it could act over large distances.
Cation-π interactions can also be classified as ionic bonding. This occurs when a cation, e.g. acetylcholine, interacts with the negative π bonds on an aromatic group of the receptor.
Ion-dipole and dipole-dipole bonds have similar interactions, but are more complicated and are weaker than ionic bonds.
Read more about this topic: Drug Action, Short Note On Receptors
Famous quotes containing the word bonds:
“For, truly speaking, whoever provokes me to a good act or thought has given me a pledge of his fidelity to virtue,—he has come under the bonds to adhere to that cause to which we are jointly attached.”
—Ralph Waldo Emerson (1803–1882)