Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors.
Other articles related to "dopamine receptor, dopamine receptors, dopamine, receptor, receptors":
... Dopamine receptors are typically stable, however sharp (and sometimes prolonged) increases or decreases in dopamine levels (via stimulants or ... other antipsychotics, have been shown to increase the binding capacity of the D2 receptor when used over long periods of time (i.e ... increasing the number of such receptors) ...
... D(1B) dopamine receptor is a protein that in humans is encoded by the DRD5 gene ... This gene encodes the D5 subtype of the dopamine receptor ... The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase ...
... This gene encodes the D1 subtype of the dopamine receptor ... The D1 subtype is the most abundant dopamine receptor in the central nervous system ... This G-protein-coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases ...
Famous quotes containing the word receptor:
“The disinterest [of my two great-aunts] in anything that had to do with high society was such that their sense of hearing ... put to rest its receptor organs and allowed them to suffer the true beginnings of atrophy.”
—Marcel Proust (18711922)