Coproporphyrinogen III

In the metabolism of porphyrin, the enzyme uroporphyrinogen III decarboxylase generates coproporphyrinogen III from uroporphyrinogen III, and coproporphyrinogen III oxidase converts it into protoporphyrinogen IX.


Types of tetrapyrroles
Bilanes
(Linear)
  • Bilirubin
  • Biliverdin
  • Stercobilinogen
  • Stercobilin
  • Urobilinogen
  • Urobilin
Phytobilins
  • Phytochromobilin
Phycobilins
  • Phycoerythrobilin
  • Phycocyanobilin
  • Phycourobilin
  • Phycoviolobilin
Macrocycle
Corrinoids
  • Methylcobalamin
  • Adenosylcobalamin
  • Cyanocobalamin
Porphyrins
Protoporphyrins
  • Protoporphyrin IX
  • Heme (b, c, a, o)
  • Zinc protoporphyrin
  • Magnesium protoporphyrin
Phytoporphyrins
  • Chlorophyll c1
  • Chlorophyll c2
  • Protochlorophyllide
Reduced
porphyrins
Porphyrinogens
  • Uroporphyrinogen (I, III)
  • Coproporphyrinogen (I, III)
  • Protoporphyrinogen IX
Chlorins
  • Chlorophyllide (a, b)
  • Chlorophyll (a, b)
  • Phaeophytin (a, b)
  • Bacteriochlorophyll c
Bacteriochlorins
  • Bacteriochlorophyll a
Isobacteriochlorins
  • Siroheme
  • Sirohydrochlorin
Corphins
  • Cofactor F430
  • biochemical families: carbohydrates
    • alcohols
    • glycoproteins
    • glycosides
  • lipids
    • eicosanoids
    • fatty acids / intermediates
    • phospholipids
    • sphingolipids
    • steroids
  • nucleic acids
    • constituents / intermediates
  • proteins
    • amino acids / intermediates
  • tetrapyrroles / intermediates
Heme metabolic intermediates
Porphyrin biosynthesis

early mitochondrial: D-Aminolevulinic acid

cytosolic: Porphobilinogen · Hydroxymethylbilane · Uroporphyrinogen III · Coproporphyrinogen III

late mitochondrial: Protoporphyrinogen IX · Protoporphyrin IX
Heme degradation
and excretion
Breakdown of heme

spleen: Heme → Biliverdin → Bilirubin

blood: Bilirubin+Albumin

liver: Bilirubin diglucuronide
Intestine, excretion in feces Stercobilinogen · Stercobilin · Urobilinogen
Kidney, excretion in urine Urobilin

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns
  • biochemical families: carbohydrates
    • alcohols
    • glycoproteins
    • glycosides
  • lipids
    • eicosanoids
    • fatty acids / intermediates
    • phospholipids
    • sphingolipids
    • steroids
  • nucleic acids
    • constituents / intermediates
  • proteins
    • amino acids / intermediates
  • tetrapyrroles / intermediates


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