Coombs can refer to:
- Coombs test, a test for the presence of antibodies or antigens
- Coombs reagent, the reagent used in the Coombs test
- Coombs' method, a type of voting designed by the psychologist Clyde Coombs
- Coombs, British Columbia, a small community in British Columbia, Canada
- , A common last name pronounced k-oo-mbs.
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