Collagen ( /ˈkɒlədʒɨn/) is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of vertebrates. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content. Collagen, in the form of elongated fibrils, is mostly found in fibrous tissues such as tendon, ligament and skin, and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell which creates collagen.
In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. Gelatin, which is used in food and industry, is collagen that has been irreversibly hydrolyzed.
Read more about Collagen: History and Background, Chemistry, Synthesis, Molecular Structure, Types and Associated Disorders, Diseases, Characteristics
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... Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene ... This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes ... This particular collagen IV subunit, however, is only found in a subset of basement membranes ...
... Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage ... Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen ...
... Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein. ...
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