Catenin

Catenin

Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Additional catenins such as gamma-catenin and delta-catenin have been identified. The name "catenin" was originally selected ('catena' means 'chain' in Latin) because it was suspected that catenins might link cadherins to the cytoskeleton.

Read more about Catenin:  Types, Function, Clinical Significance

Other articles related to "catenin":

CDH1 (gene) - Function
... domain, and an intracellular domain that binds p120-catenin and beta-catenin ... domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function ... Beta-catenin can also bind to alpha-catenin ...
CBY1
... Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers ... directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors ...
Alpha Catenin
... Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton ... vinculin and alpha-actinin can bind to alpha-catenin ... However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated ...
Clinical Significance - Catenins in Cancer
... Mutations in catenin genes can cause loss of contact inhibition that can promote cancer development and tumor formation ... growth due to lack of adhesions and contact inhibition Down-regulated levels of α-catenin Up-regulated levels of β-catenin Stimulation of the Wnt/β-catenin pathway ...
C8orf4
... that functions as a positive regulator of the Wnt/beta-catenin signaling pathway ... interacts with a repressor of beta-catenin mediated transcription at nuclear speckles ... It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes ...