Cadherins

Cell Adhesion Molecule - Families of CAMs - Calcium-dependent - Cadherins
... The cadherins are homophilic Ca2+-dependent glycoproteins ... The classic cadherins (E-, N- and P-) are concentrated at the intermediate cell junctions which link to the actin filament network through specific linking ... Each cadherin exhibits a unique pattern of tissue distribution, such as epithelial (E-cadherins), placental (P-cadherins), neural (N-cadherins), retinal (R-cadherin ...

IQGAP1 - Key Pathways - Adhesion
... Cadherins are a family of adhesion proteins that localize to the cell surface where they anchor a cell to its neighbors by clasping on to the extracellular portion ... binds beta-catenin which in turn binds E-cadherin ... E-cadherin juts into the extracellular space to grasp the extracellular domains of neighboring E-cadherins ...

Cell Junction Molecules
... There are four main types selectins, cadherins, integrins, and the immunoglobulin superfamily ... Cadherins are calcium-dependent adhesion molecules ... Cadherins are extremely important in the process of morphogenesis – fetal development ...

PTPRM - Cadherin-dependent Adhesion
... Classical cadherins are important proteins for cells to bind in the body (‘’in vivo’’) where they commonly stabilize cell–cell junctions known as adherens junctions ... Cadherins stabilize adherens junctions through the interaction of the cadherin cytoplasmic domains with catenin proteins, such as p120-catenin, beta-catenin and alpha-catenin ... Cadherins regulate cell–cell adhesion during development of the body and in adult tissue ...

Cadherin - Types - Classical
... Different members of the cadherin family are found in different locations ... CDH1 - E-cadherin (epithelial) E-cadherins are found in epithelial tissue CDH2 - N-cadherin (neural) N-cadherins are found in neurons CDH12 ...