| Gene Ontology | |
|---|---|
| Molecular function | • retinal dehydrogenase activity • aldo-keto reductase (NADP) activity • electron carrier activity • bile acid transmembrane transporter activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • androsterone dehydrogenase activity • androsterone dehydrogenase (B-specific) activity • chlordecone reductase activity |
| Cellular component | • cytoplasm • cytosol |
| Biological process | • bile acid biosynthetic process • steroid metabolic process • bile acid metabolic process • androgen metabolic process • bile acid and bile salt transport • small molecule metabolic process • daunorubicin metabolic process • doxorubicin metabolic process • cellular response to jasmonic acid stimulus |
| Sources: Amigo / QuickGO | |
5.24 – 5.26 Mb
4.43 – 4.46 Mb
3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT) (5α-androstan-17β-ol-3-one) and vice-versa.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.