AKR1C4

Identifiers Symbols AKR1C4; 3-alpha-HSD; C11; CDR; CHDR; DD-4; DD4; HAKRA External IDs OMIM: 600451 MGI: 2653678 HomoloGene: 84695 ChEMBL: 4999 GeneCards: AKR1C4 Gene EC number 1.1.1.50 1.1.1.225, 1.1.1.50

Gene Ontology
Molecular function retinal dehydrogenase activity
aldo-keto reductase (NADP) activity
electron carrier activity
bile acid transmembrane transporter activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
androsterone dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
chlordecone reductase activity
Cellular component cytoplasm
cytosol
Biological process bile acid biosynthetic process
steroid metabolic process
bile acid metabolic process
androgen metabolic process
bile acid and bile salt transport
small molecule metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
cellular response to jasmonic acid stimulus
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1109 83702 Ensembl ENSG00000198610 ENSMUSG00000021210 UniProt P17516 P70694 RefSeq (mRNA) NM_001818 NM_030611 RefSeq (protein) NP_001809 NP_085114 Location (UCSC) Chr 10:
5.24 – 5.26 Mb Chr 13:
4.43 – 4.46 Mb PubMed search

3α-hydroxysteroid dehydrogenase (3α-HSD), also known as aldo-keto reductase family 1 member C4, is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone (DHT) (5α-androstan-17β-ol-3-one) and vice-versa.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.