Working Formulation

The Working Formulation is an obsolete classification of non-Hodgkin lymphomas published in 1982. It has since been replaced by other lymphoma classifications, the latest published by the WHO in 2008, but is still used by cancer agencies for compilation of lymphoma statistics.

Low Grade

  • Malignant Lymphoma, small lymphocytic (chronic lymphocytic leukemia)
  • Malignant Lymphoma, follicular, predominantly small cleaved cell
  • Malignant Lymphoma, follicular, mixed (small cleaved and large cell)

Intermediate grade

  • Malignant Lymphoma, follicular, predominantly large cell
  • Malignant Lymphoma, diffuse, small cleaved cell
  • Malignant Lymphoma, diffuse, mixed small and large cell
  • Malignant Lymphoma, diffuse, large cell

High grade

  • Malignant Lymphoma, large cell, immunoblastic
  • Malignant Lymphoma, lymphoblastic
  • Malignant Lymphoma, small non-cleaved cells (Burkitt's lymphoma)


  • Composite
  • Mycosis fungoides
  • Histiocytic
  • Extramedullary plasmacytoma
  • Unclassifiable
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
B cell
(most CD19
  • CD20)
By development/
  • ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
  • naive B cell (CLL/SLL)
mantle zone (Mantle cell)
  • germinal center/follicular B cell (Follicular
  • Burkitt's
  • Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
  • MALT
  • Nodal marginal zone
  • Primary cutaneous marginal zone lymphoma)
RS (CD15+, CD30+)
  • Classic Hodgkin's lymphoma (Nodular sclerosis)
  • CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
  • see immunoproliferative immunoglobulin disorders
By infection
  • KSHV (Primary effusion)
  • EBV (Lymphomatoid granulomatosis
  • Post-transplant lymphoproliferative disorder)
  • HIV (AIDS-related lymphoma)
  • Helicobacter pylori (MALT lymphoma)
  • Diffuse large B-cell lymphoma
  • Intravascular large B-cell lymphoma
  • Primary cutaneous marginal zone lymphoma
  • Primary cutaneous immunocytoma
  • Plasmacytoma
  • Plasmacytosis
  • Primary cutaneous follicular lymphoma
T cell
(most CD3
  • CD4
  • CD8)
By development/
  • TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
  • prolymphocyte (Prolymphocytic)
  • CD30+ (Anaplastic large-cell lymphoma
  • Lymphomatoid papulosis type A)
  • indolent: Mycosis fungoides
  • Pagetoid reticulosis
  • Granulomatous slack skin

aggressive: Sézary's disease

  • Adult T-cell leukemia/lymphoma
  • CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
  • Pleomorphic T-cell lymphoma
  • Lymphomatoid papulosis type B

CD30+: CD30+ cutaneous T-cell lymphoma

Other peripheral
  • Hepatosplenic
  • Angioimmunoblastic
  • Enteropathy-associated T-cell lymphoma
  • Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
  • Subcutaneous T-cell lymphoma
By infection
  • HTLV-1 (Adult T-cell leukemia/lymphoma)
NK cell/
(most CD56)
T or NK
  • EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
  • Large granular lymphocytic leukemia
  • Acute biphenotypic leukaemia
  • Lymphoproliferative disorders (X-linked lymphoproliferative disease
  • Autoimmune lymphoproliferative syndrome)
  • Leukemoid reaction
  • Diffuse infiltrative lymphocytosis syndrome
Cutaneous lymphoid hyperplasia
  • Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns
  • Cutaneous lymphoid hyperplasia with nodular pattern
  • Jessner lymphocytic infiltrate of the skin


cell/phys/auag/auab/comp, igrc


proc, drug (L3/4)

Other articles related to "working formulation":

Non-Hodgkin Lymphoma
... Non-Hodgkin lymphomas were classified according to the 1982 Working Formulation which recognizes 16 types ... The Working Formulation is now considered obsolete, and the classification is commonly used primarily for statistical comparisons with previous ... The Working Formulation has been superseded twice ...

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