What is fibronectin?


Fibronectin is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans).

Read more about Fibronectin.

Some articles on fibronectin:

Fibronectin Binding Protein A - Mechanism
... The fibronectin binding protein is able to bind fibronectin present in the extracellular matrix ... Similarly, the α5β1 integrin present on host cells also binds fibronectin to create a link to its actin cytoskeleton, binding via the Arg-Gly-Asp (RGD) motif present in fibronectin ... Fibronectin is able to act as a ‘bridge’ between S ...
Fibronectin - Interactions
... Besides integrin, fibronectin binds to many other host and non-host molecules ... with proteins such fibrin, tenascin, TNF-α, BMP-1, rotavirus NSP-4, and many fibronectin binding proteins from bacteria (like FBP-A FBP-B on the N-ter ... Fibronectin has been shown to interact with CD44 COL7A1, LPA, IGFBP3, TNC, and TRIB3 ...