Vascular Smooth Muscle

Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels.

Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension.

Arteries have a great deal more smooth muscle within their walls than veins, thus their greater wall thickness. This is because they have to carry pumped blood away from the heart to all the organs and tissues that need the oxygenated blood. The endothelial lining of each is similar.

Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). Three types of adrenoceptors are present within vascular smooth muscle cells:, and . The main endogenous agonist of these cell receptors is norepinephrine (NE).

The adrenergic receptors exert opposite physiologic effects in the vascular smooth muscle under activation:

  • receptors. Under NE binding receptors cause vasoconstriction i.e. contraction of the vascular smooth muscle cells decreasing the diameter of the vessels. receptors are activated in response to shock or hypotension as a defensive reaction trying to restore the normal blood pressure. Antagonists of receptors (doxazosin, prazosin) cause vasodilation i.e. decrease in vascular smooth muscle tone with increase of vessel diameter and decrease of the blood pressure. (See also receptor antagonist)
  • receptors. Agonists of receptors in the vascular smooth muscle lead to vasoconstriction. However, in clinical practice applied intravenously drugs being agonists of receptors (clonidine) leads to powerful vasodilation and decrease in the blood pressure by presynaptic activation of receptors in the sympathetic ganglia. This presynaptic effect is predominant and completely overrides the vasoconstrictive effect of the receptors in the vascular smooth muscle.
  • receptors. Agonism at receptors causes vasodilation and hypotension, i.e. the effect is opposite of the one resulting from activation of and receptors in the vascular smooth muscle cells. Usage of agonists of receptors as hypotensive agents is less widespread due to adverse effects such as unnecessary bronchodilation in lungs and increase in blood sugar levels.

Other articles related to "vascular, muscle, smooth muscle, vascular smooth muscle":

... Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon ... transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations ... The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels ...
Margatoxin - Medicinal Significance
... Neointimal hyperplasia is the movement and proliferation of smooth muscle cells into the luminal area of a blood vessel ... Due to changes in potassium channel type the vascular smooth muscle cells switch from the contractile to proliferating phenotype ... It is suggested that Kv1.3 is important in proliferating vascular smooth muscle cells ...
George Chaldakov
23, 1940, in Burgas, Bulgaria, is a Bulgarian vascular biologist well known for his contributions in the study of secretory function of vascular smooth muscle ... In 1983 obtained PhD degree in Vascular Biology, "Ultrastructural and cytopharmacological study of aging in vascular smooth muscle cells, with special reference to their secretory function" ... past 30 years Chaldakov was involved in an interdisciplinary research in the fields of vascular biology, adipobiology and neurobiology and is one of the pioneers establishing the novel concept of ...
Louis Ignarro - Important Publications
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