Tumor Suppressor Gene

A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.

Read more about Tumor Suppressor GeneTwo-hit Hypothesis, Functions, Examples

Other articles related to "genes, tumor suppressor genes, tumor suppressor gene, tumor, tumor suppressor, gene, tumors":

Carcinogenesis - Mechanisms - Multiple Mutations
... In general, mutations in both types of genes are required for cancer to occur ... would be suppressed by normal mitosis control and tumor suppressor genes, first hypothesised by the Knudson hypothesis ... A mutation to only one tumor suppressor gene would not cause cancer either, due to the presence of many "backup" genes that duplicate its functions ...
Tumor Suppressor Gene - Examples
... The first tumor-suppressor protein discovered was the Retinoblastoma protein (pRb) in human retinoblastoma however, recent evidence has also implicated pRb as a tumor-survival factor ... Another important tumor suppressor is the p53 tumor-suppressor protein encoded by the TP53 gene ... leukemias, lymphomas, sarcomas, and neurogenic tumors ...
La Jolla Institute For Allergy And Immunology - Cancer Research - Tumor Suppressor
... instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia ... function that no one knew it had - as a tumor suppressor," said the La Jolla Institute's Toshiaki Kawakami, M.D ...
List Of Me SH Codes (G14) - MeSH G14 --- Genetic Structures - MeSH G14.340 --- Genome - MeSH G14.340.024 --- Genome Components
... regions MeSH G14.340.024.220.880.885 --- 5' untranslated regions MeSH G14.340.024.340 --- genes MeSH G14.340.024.340.077 --- alleles MeSH G14.340.024.340.137 --- gene ...
Loss Of Heterozygosity - In Cancer
... it indicates the absence of a functional tumor suppressor gene in the lost region ... a loss, because there still is one functional gene left on the other chromosome of the chromosome pair ... However, the remaining copy of the tumor suppressor gene can be inactivated by a point mutation, leaving no tumor suppressor gene to protect the body ...