In enzymology, a thymidine phosphorylase (EC 22.214.171.124) is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.
Thymidine phosphorylase is involved and used in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme participates in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and bladder cancer.
Other articles related to "phosphorylase, thymidine phosphorylase":
... Gene EC number 126.96.36.199 Gene Ontology Molecular function • phosphorylase activity • platelet-derived growth factor receptor binding • growth factor ... Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin ... Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 ...
... EC 2.4) 2.4.1 Hexosyl- transferases Glucosyl- Phosphorylase Starch Glycogen Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-beta-glucan ...