SPRY2

SPRY2

Identifiers Symbols SPRY2; hSPRY2 External IDs OMIM: 602466 MGI: 1345138 HomoloGene: 4267 GeneCards: SPRY2 Gene

Gene Ontology
Molecular function	• protein binding • protein kinase binding • protein serine/threonine kinase inhibitor activity • protein serine/threonine kinase activator activity
Cellular component	• cytosol • microtubule • plasma membrane • ruffle membrane
Biological process	• epidermal growth factor receptor signaling pathway • sensory perception of sound • negative regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • positive regulation of gene expression • negative regulation of peptidyl-threonine phosphorylation • positive regulation of peptidyl-serine phosphorylation • negative regulation of Ras GTPase activity • negative regulation of fibroblast growth factor receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • inner ear morphogenesis • negative regulation of apoptotic process • negative regulation of MAP kinase activity • cell fate commitment • negative regulation of Ras protein signal transduction • branching morphogenesis of an epithelial tube • negative regulation of neurotrophin TRK receptor signaling pathway • positive regulation of protein kinase B signaling cascade • lung morphogenesis • lung growth • negative regulation of ERK1 and ERK2 cascade • positive regulation of ERK1 and ERK2 cascade • positive regulation of protein serine/threonine kinase activity
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10253 24064 Ensembl ENSG00000136158 ENSMUSG00000022114 UniProt O43597 Q9QXV8 RefSeq (mRNA) NM_005842 NM_011897 RefSeq (protein) NP_005833 NP_036027 Location (UCSC) Chr 13:
80.91 – 80.92 Mb Chr 14:
105.89 – 105.9 Mb PubMed search

Sprouty homolog 2 (Drosophila), also known as SPRY2, is a protein which in humans is encoded by the SPRY2 gene.