Spina Bifida

Spina bifida (Latin: "split spine") is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube. Some vertebrae overlying the spinal cord are not fully formed and remain unfused and open. If the opening is large enough, this allows a portion of the spinal cord to protrude through the opening in the bones. There may or may not be a fluid-filled sac surrounding the spinal cord. Other neural tube defects include anencephaly, a condition in which the portion of the neural tube that will become the cerebrum does not close, and encephalocele, which results when other parts of the brain remain unfused.

Spina bifida malformations fall into three categories: spina bifida occulta, spina bifida cystica with meningocele, and spina bifida cystica with myelomeningocele. The most common location of the malformations is the lumbar and sacral areas. Myelomeningocele is the most significant and common form, and this leads to disability in most affected individuals. The terms spina bifida and myelomeningocele are usually used interchangeably.

Spina bifida can be surgically closed after birth, but this does not restore normal function to the affected part of the spinal cord. Intrauterine surgery for spina bifida has also been performed, and the safety and efficacy of this procedure are currently being investigated. The incidence of spina bifida can be decreased by up to 70% when the mother takes daily folic acid supplements prior to conception. This was a study done on mothers who already have a child with spina bifida. The Spina Bifida Association says.

Read more about Spina BifidaPathophysiology, Prevention, Treatment, Epidemiology, Fetal Surgery Research, Notable People

Other articles related to "spina bifida":

MOMS Study - Fetal Surgery Research - Endoscopic Fetal Surgery
... this technique provides superior visualization of fetoscopic spina bifida closure, is called PACI (partial amniotic fluid insufflation), and has been safe for mothers and fetuses alike in ... approach do not occur following minimally-invasive fetoscopic closure of spina bifida aperta ... following the fetoscopic approach, postnatal spina bifida surgery can now be avoided in most patients ...
MOMS Trial - History
... Joseph Bruner, attempted to close spina bifida in 4 human fetuses using a skin graft from the mother using specialized telescope called a laparoscope ... Hospital of Philadelphia performed open fetal surgery for spina bifida in an early gestation fetus (22 week gestation fetus) with a successful outcome ... Subsequently, 4 medical centers conducted 253 open spina bifida repairs prior to the MOMs trial ...
MOMS Trial - Outcomes of The Trial
... The trial demonstrated that outcomes after prenatal spina bifida treatment are improved to the degree that the benefits of the surgery outweigh the maternal risks ... Specifically, the study found that Babies that underwent fetal repair of spina bifida were half as likely to need a ventricular shunt ... Based on these outcomes, fetal repair of spina bifida is now considered a standard of care at some fetal centers ...
Spina Bifida - Notable People
... Notable people with spina bifida include Tanni Grey-Thompson - Welsh Paralympic athlete, member of British House of Lords Blaine Harrison - lead singer, keyboards, rhythm guitarist and former ...
MOMS Study
... Spina bifida (Latin "split spine") is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube ... Spina bifida malformations fall into three categories spina bifida occulta, spina bifida cystica with meningocele, and spina bifida cystica with myelomeningocele ... The terms spina bifida and myelomeningocele are usually used interchangeably ...