Mechanism of Action
The siDNA family, lead by Dbait consists of 32 base pairs deoxyribonucleotide forming an intramolecular double helix, which mimicks DNA double-strand break lesions. Dbait binds to and hyperactivate DNA-PK, an enzyme involved in DNA breaks signaling and repair. DNA-PK hyperactivation induces pan-nuclear phosphorylation of histone H2AX among all the chromatine. H2AX phosphorylation is the signal, which allows double-strand break repair proteins (from NHEJ and Homologous recombination pathways) to form DNA repair complexes selectively on DNA double-strand breaks. Dbait-dependent unspecific phosphorylation of H2AX results in inefficient double strand break recognition and repair.
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Other articles related to "mechanism of action, action, mechanism of":
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In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.
For example, the mechanism of action of aspirin involves irreversible inhibition of the enzyme cyclooxygenase, therefore suppressing the production of prostaglandins and thromboxanes, thereby reducing pain and inflammation.
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