Signal interfering DNA (siDNA) is a class of short modified double stranded DNA molecules, 8-64 base pairs in length. siDNA molecules are capable of inhibiting DNA repair activities by interfering with multiple repair pathways. In general, these molecules act by mimicking DNA breaks and interfering with recognition and repair of DNA damage induced on chromosomes by irradiation or genotoxic products (video of siDNA mechanism).

Read more about Si DNAMechanism of Action, Possible Therapeutic Application

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Si DNA - Possible Therapeutic Application
... Most of the anticancer therapies act by induction of DNA damage (chemotherapy and radiation therapy) ... DNA breaks are the most lethal damage for cells, as one single double-strand break if unrepaired is sufficient to lead to cell death ... Dbait enhances the efficacy of the DNA damaging agents as demonstrated with radiation therapy and/or chemotherapy in multiple in vivo experimental models such as melanoma, glioblastoma and ...

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