Identifiers Symbols PDGFRA; CD140A; PDGFR-2; PDGFR2; RHEPDGFRA External IDs OMIM: 173490 MGI: 97530 HomoloGene: 31361 ChEMBL: 2007 GeneCards: PDGFRA Gene EC number

Gene Ontology
Molecular function transmembrane receptor protein tyrosine kinase activity
platelet-derived growth factor alpha-receptor activity
vascular endothelial growth factor-activated receptor activity
platelet-derived growth factor receptor binding
protein binding
ATP binding
vascular endothelial growth factor binding
protein homodimerization activity
platelet-derived growth factor binding
Cellular component nucleus
plasma membrane
integral to plasma membrane
external side of plasma membrane
intrinsic to plasma membrane
Biological process luteinization
in utero embryonic development
cell activation
epidermal growth factor receptor signaling pathway
elevation of cytosolic calcium ion concentration
estrogen metabolic process
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
negative regulation of platelet activation
positive regulation of phospholipase C activity
positive regulation of phosphatidylinositol 3-kinase cascade
peptidyl-tyrosine phosphorylation
virus-host interaction
signal transduction involved in regulation of gene expression
extracellular matrix organization
lung development
adrenal gland development
positive regulation of cell migration
male genitalia development
Leydig cell differentiation
platelet-derived growth factor receptor-alpha signaling pathway
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
odontogenesis of dentin-containing tooth
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
positive regulation of DNA replication
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
embryonic digestive tract morphogenesis
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
regulation of chemotaxis
cardiac myofibril assembly
palate development
face morphogenesis
cell chemotaxis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
cellular response to amino acid stimulus
metanephric glomerular capillary formation
regulation of actin cytoskeleton reorganization
regulation of mesenchymal stem cell differentiation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5156 18595 Ensembl ENSG00000134853 ENSMUSG00000029231 UniProt P16234 P26618 RefSeq (mRNA) NM_006206 NM_001083316 RefSeq (protein) NP_006197 NP_001076785 Location (UCSC) Chr 4:
55.1 – 55.16 Mb Chr 5:
75.15 – 75.2 Mb PubMed search

Alpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

Read more about PDGFRA:  Interactions, See Also