PDGFRA

PDGFRA

Identifiers Symbols PDGFRA; CD140A; PDGFR-2; PDGFR2; RHEPDGFRA External IDs OMIM: 173490 MGI: 97530 HomoloGene: 31361 ChEMBL: 2007 GeneCards: PDGFRA Gene EC number 2.7.10.1

Gene Ontology
Molecular function	• transmembrane receptor protein tyrosine kinase activity • platelet-derived growth factor alpha-receptor activity • vascular endothelial growth factor-activated receptor activity • platelet-derived growth factor receptor binding • protein binding • ATP binding • vascular endothelial growth factor binding • protein homodimerization activity • platelet-derived growth factor binding
Cellular component	• nucleus • cytoplasm • plasma membrane • integral to plasma membrane • external side of plasma membrane • intrinsic to plasma membrane
Biological process	• luteinization • in utero embryonic development • cell activation • epidermal growth factor receptor signaling pathway • elevation of cytosolic calcium ion concentration • estrogen metabolic process • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • negative regulation of platelet activation • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase cascade • peptidyl-tyrosine phosphorylation • virus-host interaction • signal transduction involved in regulation of gene expression • extracellular matrix organization • lung development • adrenal gland development • positive regulation of cell migration • male genitalia development • Leydig cell differentiation • platelet-derived growth factor receptor-alpha signaling pathway • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • wound healing • odontogenesis of dentin-containing tooth • positive regulation of phosphatidylinositol 3-kinase activity • innate immune response • positive regulation of DNA replication • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • embryonic digestive tract morphogenesis • embryonic cranial skeleton morphogenesis • embryonic skeletal system morphogenesis • regulation of chemotaxis • cardiac myofibril assembly • palate development • face morphogenesis • cell chemotaxis • retina vasculature development in camera-type eye • positive regulation of ERK1 and ERK2 cascade • platelet aggregation • cellular response to amino acid stimulus • metanephric glomerular capillary formation • regulation of actin cytoskeleton reorganization • regulation of mesenchymal stem cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5156 18595 Ensembl ENSG00000134853 ENSMUSG00000029231 UniProt P16234 P26618 RefSeq (mRNA) NM_006206 NM_001083316 RefSeq (protein) NP_006197 NP_001076785 Location (UCSC) Chr 4:
55.1 – 55.16 Mb Chr 5:
75.15 – 75.2 Mb PubMed search

Alpha-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRA gene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.