Minocycline

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Minocycline (INN) is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group. It is a bacteriostatic antibiotic, classified as a long-acting type. As a result of its long half-life it generally has serum levels 2–4 times that of the simple water-soluble tetracyclines (150 mg giving 16 times the activity levels compared with 250 mg of tetracycline at 24–48 hours).

Minocycline is the most lipid-soluble of the tetracycline-class antibiotics, giving it the greatest penetration into the prostate and brain, but also the greatest amount of central nervous system (CNS)-related side effects, such as vertigo. A common side effect is diarrhea. Uncommon side effects (with prolonged therapy) include skin discolouration and autoimmune disorders that are not seen with other drugs in the class.

Minocycline is a relatively poor tetracycline-class antibiotic choice for urinary pathogens sensitive to this antibiotic class, as its solubility in water and levels in the urine are less than all other tetracyclines. Minocycline is metabolized by the liver and has poor urinary excretion.

Minocycline is not a naturally-occurring antibiotic, but was synthesized semi-synthetically from natural tetracycline antibiotics by Lederle Laboratories in 1972, and marketed by them under the brand name Minocin.

Read more about MinocyclineIndications, Cautions, Side Effects, Anti-inflammatory and Neuroprotective, Trade Names and Availability

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Therapies Under Investigation For Multiple Sclerosis - Other Investigations On Possible Treatments
... Minocycline the antibiotic minocycline has shown an effect on clinical and magnetic resonance imaging (MRI) outcomes and serum immune molecules in MS patients over 24 months ... patient with gadolinium-enhancing lesions on MRI at 12 and 24 months was on half-dose minocycline ... this study were supported by systemic immunological changes and call for further investigation of minocycline in MS ...
Minocycline - Trade Names and Availability
... Minocycline is no longer covered by patent and is therefore marketed under several trade names Minomycin Akamin Minocin Minoderm Cyclimycin Arestin (1 ... Minoz (In Romania) StoneBridge Pharma also markets Minocycline as Cleeravue-M in combination with SteriLid eyelid cleanser in the treatment of rosacea ...
Tetracycline Antibiotics - Administration
... Partial exceptions to these rules occur for doxycycline and minocycline, which may be taken with food (though not iron, antacids, or calcium supplements) ... Minocycline, can be taken with dairy products because it does not chelate calcium as readily, although dairy products do decrease absorption of minocycline slightly ...