Methylation

In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with, to be specific, a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences.

In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA metabolism. Methylation of heavy metals can also occur outside of biological systems. Chemical methylation of tissue samples is also one method for reducing certain histological staining artifacts.

Read more about MethylationIn Chemistry, 5-O-Methylations

Other articles related to "methylation":

Somatic Evolution In Cancer - Somatic Evolution in Progression - Somatic Evolution By Epigenetics
... or expression of genes by changes in the methylation of CG pairs of nucleotides in the promoter regions of the genes ... These methylation patterns are copied to the new chromosomes when cells replicate their genomes and so methylation alterations are heritable and subject to natural selection ... Methylation changes are thought to occur more frequently than mutations in the DNA, and so may account for many of the changes during neoplastic progression (the process by which normal tissue ...
Methylated DNA Immunoprecipitation - Downstream Bioinformatics Analysis
... The DNA methylation level estimations can be confounded by varying densities of methylated CpG sites across the genome when observing data generated by MeDIP ... developed a tool to estimate absolute methylation levels from data generated by MeDIP by modeling the density of methylated CpG sites ... This tool is called Bayesian tool for methylation analysis (Batman) ...
Methylated DNA Immunoprecipitation - Background
... DNA methylation, referring to the reversible methylation of the 5 position of cytosine by methyltransferases, is a major epigenetic modification in ... The modification may also occur at other sites, but methylation at either of these sites can repress gene expression by either interfering with the binding of transcription factors or modifying chromatin ... Disease condition studies have largely fueled the effort in understanding the role of DNA methylation ...
Small Nucleolar RNA Sno Z7/sno R77
... in directing site-specific 2'-O-methylation of substrate RNAs ... snoZ7 RNA guides the methylation of 25S rRNA position A1372, whereas SnoR77Y guides the methylation of 18S rRNA at position U580 ...