Lusignan can refer to:
- Lusignan dynasty, a European ruling family
- Château de Lusignan, the seat of the lords of Lusignan in Lusignan, Vienne, France
- Lusignan, Vienne, a town in Vienne, France
- Canton of Lusignan, a canton in Vienne, France
- Lusignan-Petit, a town in Lot-et-Garonne, France
- Lusignan (Guyana), a village in Guyana
- Franz Joseph, Marquis de Lusignan, an Austrian general (1753-1832)
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