Lupus

Systemic lupus erythematosus (i/sɪˈstɛmɪk ˈluːpəs ˌɛrɪθiːməˈtoʊsəs/), often abbreviated to SLE or lupus, is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. It is a Type III hypersensitivity reaction in which antibody-immune complexes precipitate and cause a further immune response.

Lupus is Latin for wolf. In the 18th century, when lupus was just starting to be recognized as a disease, it was thought that it was caused by the bite of a wolf. This may have been because of the distinctive rash characteristic of lupus. (Once full-blown, the round, disk-shaped rashes heal from the inside out, leaving a bite-like imprint.)

SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially in women in child-bearing years ages 15 to 35, and is also more common in those of non-European descent.

There is no cure for SLE. It is treated with immunosuppression, mainly with cyclophosphamide, corticosteroids and other immunosuppressants. SLE can be fatal. Survival for people with SLE in the United States, Canada, and Europe has risen to approximately 95% at five years, 90% at 10 years, and 78% at 20 years, and now approaches that of matched controls without lupus.

Childhood systemic lupus erythematosus generally presents between the ages of 3 and 15, with girls outnumbering boys 4:1, and typical skin manifestations being butterfly eruption on the face and photosensitivity.



Read more about Lupus:  Signs and Symptoms, Causes, Pathophysiology, Prevention, Treatment, Prognosis, Epidemiology, Notable Cases, Research

Other articles related to "lupus":

Lupus Band Test
... Lupus band test is done upon skin biopsy, with direct immunofluorescence staining, in which, if positive, IgG and complement depositions are found at the dermoepidermal junction ... This test can be helpful in distinguishing systemic lupus erythematosus (SLE) from cutaneous lupus, because in SLE the lupus band test will be positive in both ...
Lupus Headache - Diagnosis
... (such as lumbar puncture or magnetic resonance imaging, MRI) are needed in lupus patients presenting with headache ... and they have not been able to distinguish a special "lupus headache" from other headache types in people with lupus ...
Lupus Erythematosus–lichen Planus Overlap Syndrome
... Lupus erythematosus–lichen planus overlap syndrome (also known as "Lichen planus–lupus erythematosus overlap syndrome") is a true overlap syndrome with features ... Lichen planus–lupus erythematosus overlap syndrome is a rare variant of lichen planus characterized by lesions that share features with lupus erythematosus ...
Lupus Headache
... Lupus headache is a proposed, specific headache disorder in patients suffering from systemic lupus erythematosus (SLE) ... The existence of a special lupus headache is contested, although few high-quality studies are available to form definitive conclusions ...
Lupus - Research
... Since lupus is considered to be currently incurable, current research is being geared towards finding a possible cause, a cure, and more effective treatment plans to ...

Famous quotes containing the word lupus:

    Regna regnis lupi, The State is a wolf unto the State. It is not a pessimistic lamentation like the old homo homini lupus [Man is a wolf to Man], but a positive creed and political ideal.
    Johan Huizinga (1872–1945)